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Андрология и генитальная хирургия

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Гены несиндромальных форм азооспермии и олигозооспермии тяжелой степени

https://doi.org/10.17650/2070-9781-2019-20-2-16-28

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Аннотация

Сперматогенез — сложный биологический процесс дифференцировки и созревания мужских половых клеток, в который у человека вовлечено более 2300 генов. До недавнего времени изучалась роль лишь малой части этих генов в развитии патозооспермии и мужского бесплодия, но в последние годы использование технологий анализа генома, таких как секвенирование экзома и хромосомный микроматричный анализ, позволило существенно расширить возможности исследований, предметом которых стали многие гены и локусы генома, генные мутации и полиморфизмы, вариации числа копий, приводящие к различным генетическим синдромам и заболеваниям, в том числе к мужскому и женскому бесплодию. В данной статье описан ряд генов, которые связаны с развитием несиндромальных форм мужского бесплодия с азооспермией и олигозооспермией тяжелой степени.

Об авторах

О. А. Соловова
ФГБНУМедико-генетический научный центр
Россия

Ольга Александровна Соловова

115522 Москва, ул. Москворечье, 1



В. Б. Черных
ФГБНУМедико-генетический научный центр; ФГБОУ ВО «Российский национальный исследовательский медицинский университет им. Н.И. Пирогова» Минздрава России
Россия
115522 Москва, ул. Москворечье, 1;117437Москва, ул. Островитянова, 1


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Для цитирования:


Соловова О.А., Черных В.Б. Гены несиндромальных форм азооспермии и олигозооспермии тяжелой степени. Андрология и генитальная хирургия. 2019;20(2):16-28. https://doi.org/10.17650/2070-9781-2019-20-2-16-28

For citation:


Solovova O.A., Chernykh V.B. Genetic causes of nonsyndromic forms of azoospermia and severe oligozoospermia in infertility men. Andrology and Genital Surgery. 2019;20(2):16-28. (In Russ.) https://doi.org/10.17650/2070-9781-2019-20-2-16-28

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ISSN 2070-9781 (Print)
ISSN 2412-8902 (Online)