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Андрология и генитальная хирургия

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Витамин D, мужское здоровье и мужская репродукция

https://doi.org/10.17650/2070-9781-2013-4-36-44

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Аннотация

В литературном обзоре представлены современные данные, доказывающие важную физиологическую роль витамина D и его дефицита для мужского здоровья в целом и мужской репродукции в частности. На сегодняшний день эти доказательства базируются в основном на экспериментальных работах с животными и на клинических наблюдательных исследованиях, доказательная база которых пока недостаточна для формулировки общей концепции дефицита витамина D в современной репродуктологии. Однако, учитывая высокую распространенность мужского бесплодия, недиагностированного андрогенного дефицита и дефицита витамина D, находящихся между собой в теснейших достоверных патофизиологических связях, можно предположить, что дальнейшие исследования в области эндокринологии витамина D могут привести к появлению новых методов оценки мужской репродуктивной функции и разработке новых патогенетических терапевтических подходов к лечению мужского бесплодия. Эти перспективы особенно важны, если учесть, что бесплодием страдают не менее 10–20 % супружеских пар, и эта цифра постоянно увеличивается. Несмотря на то что витамин D пока не входит в перечень препаратов для лечения мужского бесплодия, его влияние на андрогенный статус мужчины, являющийся эндокринологическим базисом половой и репродуктивной функций, и позитивные эффекты на сперматогенез в экспериментальных исследованиях следует считать доказанными. Кроме того, необходимы крупномасштабные клинические рандомизированные исследования для определения оптимального физиологического уровня 25(OH)-витамина D для профилактики и лечения нарушений мужской фертильности.

Об авторах

Игорь Адамович Тюзиков
ООО «Медицинский центр диагностики и профилактики»
Россия
Ярославль


С. Ю. Калинченко
ФПК МР ФГБОУ ВПО РУДН
Россия
кафедра эндокринологии, Москва


Л. О. Ворслов
ФПК МР ФГБОУ ВПО РУДН
Россия
кафедра эндокринологии, Москва


Ю. А. Тишова
ФПК МР ФГБОУ ВПО РУДН
Россия
кафедра эндокринологии, Москва


Список литературы

1. Choy J.T., Ellsworth P. Overview of current approaches to the evaluation and management of male infertility. Urol Nurs 2012;32(6):286–94.

2. Rouchou B. Consequences of infertility in developing countries. Perspect Public Health 2013;133(3):174–9.

3. Jungwirth A., Diemer T., Dohle G.R. et al. Male Infertility. EAU, 2013. 60 р.

4. Espinosa G., Esposito R., Kazzazi A., Djavan B. Vitamin D and benign prostatic hyperplasia – a review. Can J Urol 2013;20(4):6820–5.

5. Holt S.K., Kolb S., Fu R. et al. Circulating levels of 25-hydroxyvitamin D and prostate cancer prognosis. Cancer Epidemiol 2013;37(5):666–70.

6. Marusić G., Jeremić D., Vojinov S. et al. Vitamin D and prostate cancer. Med Pregl 2013;66(5–6):259–62.

7. Motrich R.D., van Etten E., Depovere J. et al. Impact of vitamin D receptor activity on experimental autoimmune prostatitis. J Autoimmun 2009;32(2):140–8.

8. Lerchbaum E., Obermayer-Pietsch В. Vitamin D and fertility: a systematic review. Eur J Endocrinol 2012;166:765–78.

9. Шварц Г.Я. Витамин Д и Д-гормон. М.: Анахарсис, 2005. 152 с.

10. Castro L.C. The vitamin D endocrine system. Arq Bras Endocrinol Metabol 2011;55(8):566–75.

11. Lee D.M., Tajar A., Pye S.R. et al. EMAS study group. Association of hypogonadism with vitamin D status: the European Male Ageing Study. Eur J Endocrinol 2012;166:77–85.

12. Nimptsch K., Platz E.A., Willett W.C., Giovannucci E. Association between plasma 25-OH vitamin D and testosterone levels in men. Clin Endocrinol 2012;77:106–12.

13. Pilz S., Frisch S., Koertke H. et al. Effect of vitamin D supplementation on testosterone levels in men. Horm Metab Res 2011;43:223–5.

14. Wehr E., Pilz S., Boehm B.O. et al. Low free testosterone is associated with heart failure mortality in older men referred for coronary angiography. Eur J Heart Fail 2011;13:482–8.

15. Wehr E., Pilz S., Boehm B.O. et al. Association of vitamin D status with serum androgen levels in men. Clin Endocrinol (Oxf) 2010;73(2):243–8.

16. Rojansky N., Brzezinski A., Schenker J.G. Seasonality in human reproduction: an update. Human Reprod 1992;7:735–45.

17. Yoshida M., Kawano N., Yoshida K. Control of sperm motility and fertility: diverse factors and common mechanisms. Cell Molecul Life Sciences 2008;65:3446–57.

18. Ryan C.S., Petkov V.I., Adler R.A. Osteoporosis in men: the value of laboratory testing. Osteoporos Int 2011;22(6):1845–53.

19. Pilz S., März W., Wellnitz B. et al. Association of vitamin D deficiency with heart failure and sudden cardiac death in a large cross-sectional study of patients referred for coronary angiography. J Clin

20. Endocrinol Metab 2008;93:3927–35.

21. Wehr E., Pilz S., Boehm B.O. et al. Sex steroids and mortality in men referred for coronary angiography. Clin Endocrinol 2010;73:613–21.

22. Glass A.R., Swerdloff R.S., Bray G.A. et al. Low serum testosterone and sex-hormone-binding-globulin in massively obese men. J Clin Endocrinol Metab 1977;45:1211–9.

23. Nangia V., Matin A., Bhojwani K. et al. Testicular maturation arrest to testis cancer: spectrum of expression of the vitamin D receptor and vitamin D treatment in vitro. J Urol 2007;178:1092–6.

24. Mordan-McCombs S., Brown T., Wang W.L. et al. Tumor progression in the LPB-Tag transgenic model of prostate cancer is altered by vitamin D receptor and serum testosterone status. J Steroid Biochem

25. Molecul Biol 2010;121:368–71.

26. Blomberg J.M. Vitamin D metabolism, sex hormones, and male reproductive function. Reproduction 2012;144(2):135–52.

27. Wehr E., Pilz S., Schweighofer N. et al. Association of hypovitaminosis D with metabolic disturbances in polycystic ovary syndrome. Eur J Endocrinol 2009;161:575–82.

28. Ngo D.T., Chan W.P., Rajendran S. et al. Determinants of insulin responsiveness in young women: impact of polycystic ovarian syndrome, nitric oxide, and vitamin D. Nitric Oxide 2011;25:326–30.

29. Li H.W., Brereton R.E., Anderson R.A. et al. Vitamin D deficiency is common and associated with metabolic risk factors in patients with polycystic ovary syndrome. Metabolism 2011;60:1475–81.

30. Panidis D., Balaris C., Farmakiotis D. et al. Serum parathyroid hormone concentrations are increased in women with polycystic ovary syndrome. Clin Chem 2005;51:1691–7.

31. Wortsman J., Matsuoka L.Y., Chen T.C. et al. Decreased bioavailability of vitamin D in obesity. Am J Clin Nutrition 2000;72:690–3.

32. Compston J.E., Vedi S., Ledger J.E. et al. Vitamin D status and bone histomorphometry in gross obesity. Am J Clin Nutrition 1981;34:2359–63.

33. Hahn S., Haselhorst U., Tan S. et al. Low serum 25-hydroxyvitamin D concentrations are associated with insulin resistance and obesity in women with polycystic ovary syndrome. Experiment Clin Endocrinol Diabet 2006;114:577–83.

34. Kamycheva E., Joakimsen R.M., Jorde R. Intakes of calcium and vitamin D predict body mass index in the population of Northern Norway. J Nutrition 2003;133:102–6.

35. Pittas A.G., Lau J., Hu F.B., Dawson-Hughes B. The role of vitamin D and calcium in type 2 diabetes. A systematic review and meta-analysis. J Clin Endocrinol Metab 2007;92:2017–29.

36. Maestro B., Dávila N., Carranza M.C., Calle C. Identification of a vitamin D response element in the human insulin receptor gene promoter. J Steroid Biochem Molecul Biol 2003;84:223–30.

37. Maestro B., Molero S., Bajo S. et al. Transcriptional activation of the human insulin receptor gene by 1,25-dihydroxyvitamin D(3). Cell Biochem Function 2002;20:227–32.

38. Milner R.D., Hales C.N. The role of calcium and magnesium in insulin secretion from rabbit pancreas studied in vitro. Diabetol 1967;3:47–9.

39. Bikle D. Nonclassic actions of vitamin D. J Clin Endocrinol Metab 2009;94:26–34.

40. Shoelson S.E., Herrero L., Naaz A. Obesity, inflammation, and insulin resistance. Gastroenterol 2007;132:2169–80.

41. Божедомов В.А., Громенко Д.С., Ушакова И.В. и др. Причины оксидативного стресса сперматозоидов. Пробл репрод 2008;6:67–73.

42. Fujii J., Tsunoda S. Redox regulation of fertilisation and the spermatogenic process. Asian J Androl 2011;13(3):420–3.

43. Tremellen K. Oxidative stress and male infertility – a clinical perspective. Hum Reprod Update 2008;14(3):243–58.

44. Foresta C., Strapazzon G., De Toni L. et al. Bone mineral density and testicular failure: evidence for a role of vitamin D 25-hydroxylase in human testis. J Clin Endocrinol Metab 2011;96(4):646–52.

45. Shinkyo R., Sakaki T., Kamakura M. et al. Metabolism of vitamin D by human microsomal CYP2R1. Bioch Biophys Res Commun 2004;324(1):451–7.

46. Anagnostis P., Karras S., Goulis D.G. Vitamin D in human reproduction: a narrative review. Int J Clin Pract 2013;67(3):225–35.

47. Doroszko A., Niedzielska E., Gronowicz E. Influence of vitamin D on fertility and fetal development – review of literature. Ginekol Pol 2008;79(3):198–202.

48. Blomberg J.M., Bjerrum P.J., Jessen T.E. et al. Vitamin D is positively associated with sperm motility and increases intracellular calcium in human spermatozoa. Hum Reprod 2011;26(6):1307–17.

49. Aquila S., Guido C., Middea E. et al. Human male gamete endocrinology: 1α,25-dihydroxyvitamin D3 (1,25(OH)2D3) regulates different aspects of human sperm biology and metabolism. Reprod Biol Endocrinol 2009;7:140.

50. Johnson J.A., Grande J.P., Roche P.C., Kumar R. Immunohistochemical detection and distribution of the 1,25-dihydroxyvitamin D3 receptor in rat reproductive tissues. Histochem Cell Biol 1996;105:7–15.

51. Hirai T., Tsujimura A., Ueda T. et al. Effect of 1,25-dihydroxyvitamin D on testicular morphology and gene expression in experimental cryptorchid mouse: testis specific cDNA microarray analysis and potential implication in male infertility. J Urol 2009;181:1487–92.

52. Corbett S.T., Hill O, Nangia A.K. Vitamin D receptor found in human sperm. Urol 2006;68:1345–9.

53. Blomberg Jensen M., Nielsen J.E., Jørgensen A. et al. Vitamin D receptor and vitamin D metabolizing enzymes are expressed in the human male reproductive tract. Hum Reprod 2010;25:1303–11.

54. Walters M.R. 1,25-dihydroxyvitamin D3 receptors in the seminiferous tubules of the rat testis increase at puberty. Endocrinol 1984;114:2167–74.

55. Holick M.F. Vitamin D deficiency. New Engl J Med 2007;357:266–81.

56. Kinuta K., Tanaka H., Moriwake T. et al. Vitamin D is an important factor in estrogen biosynthesis of both female and male gonads. Endocrinol 2000;141:1317–24.

57. Jones G., Strugnell S.A., DeLuca H.F. Current understanding of the molecular actions of vitamin D. Physiol Reviews 1998;78:1193–231.

58. Jenster G., Spencer T.E., Burcin M.M. et al. Steroid receptor induction of gene transcription: a two-step model. PNAS 1997;94:7879–84.

59. Bouillon R., Carmeliet G., Verlinden L. et al. Vitamin D and human health: lessons from vitamin D receptor null mice. Endocrine Reviews 2008;29:726–6.

60. Blomberg J.M., Dissing S. Non-genomic effects of vitamin D in human spermatozoa. Steroids 2012;77(10):903–9.

61. Merke J., Hügel U., Ritz E. Nuclear testicular 1,25-dihydroxyvitamin D3 receptors in Sertoli cells and seminiferous tubules of adult rodents. Biochem Biophys Res Commun 1985;127:303–9.

62. Adorini L., Penna G. Control of autoimmune diseases by the vitamin D endocrine system. Nat Clin Pract Rheumatol 2008;4(8):404–12.

63. Motrich R.D., van Etten E., Depovere J. et al. Impact of vitamin D receptor activity on experimental

64. autoimmune prostatitis. Autoimmun 2009;32(2):140–8.

65. Habib F.K., Maddy S.Q., Gelly K.J. Characterisation of receptors for 1,25-dihydroxyvitamin D3 in the human testis. J Steroid Biochem 1990;35:195–9.

66. Corbett S.T., Hill O., Nangia A.K. Vitamin D receptor found in human sperm. Urol 2006;68:1345–9.

67. Aquila S., Guido C., Perrotta I. et al. Human sperm anatomy: ultrastructural localization of 1α,25-dihydroxyvitamin D receptor and its possible role in the human male gamete. J Anatom 2008;213:555–64.

68. Hirai T., Tsujimura A., Ueda T. et al. Effect of 1,25-dihydroxyvitamin D on testicular morphology and gene expression in experimental cryptorchid mouse: testis specific cDNA microarray analysis and potential implication in male infertility. J Urol 2009;181:1487–92.

69. Selva D.M., Hirsch-Reinshagen V., Burgess B. et al. The ATP-binding cassette transporter 1 mediates lipid efflux from Sertoli cells and influences male fertility. J Lipid Res 2004;45:1040–50.

70. Zanatta L., Zamoner A., Gonçalves R. et al. Effect of 1α,25-dihydroxyvitamin D(3) in plasma membrane targets in immature rat testis: ionic channels and g-glutamyl transpeptidase activity. Arch Biochem

71. Biophysics 2011;515:46–53.

72. Zanatta L., Zamoner A., Zanatta A.P. et al. Nongenomic and genomic effects of 1α,25-(OH)2 vitamin D3 in rat testis. Life Sciences 2011;89:515–23.

73. Nangia V., Matin A., Bhojwani K. et al. Testicular maturation arrest to testis cancer: spectrum of expression of the vitamin D receptor and vitamin D treatment in vitro. J Urol 2007;178:1092–6.

74. Somjen D., Katzburg S., Stern N. et al. 25Hydroxy-vitamin D(3)-1ahydroxylase expression and activity in cultured human osteoblasts and their modulation by parathyroid hormone, estrogenic compounds and dihydrotestosterone. J Steroid Biochem Molecul Biol 2007;107:238–44.

75. Menegaz D., Rosso A., Royer C. et al. Role of 1α,25(OH)2 vitamin D3 on a-[1-(14)C]MeAIB accumulation in immature rat testis. Steroids 2009;74:264–9.

76. Akerstrom V.L., Walters M.R. Physiological effects of 1,25-dihydroxyvitamin D3 in TM4 Sertoli cell line.

77. Am J Physiol 1992;262:884–9.

78. Guido C., Perrotta I., Tripepi S. et al. Human sperm anatomy: ultrastructural localization of 1α,25-dihydroxyvitamin D receptor and its possible role in the human male gamete. J Anatom 2008;213:555–64.

79. Hamden K., Carreau S., Jamoussi K. et al. Inhibitory effects of 1α, 25-dihydroxyvitamin D3 and Ajuga iva extract on oxidative stress, toxicity and hypo-fertility in diabetic rat testes. J Physiol Biochem 2008;64:231–9.

80. Kwiecinski G.G., Petrie G.I., DeLuca H.F. 1,25-Dihydroxyvitamin D3 restores fertility of vitamin D-deficient female rats. Am J Physiol 1989;256:483–7.

81. Kwiecinski G.G., Petrie G.I., DeLuca H.F. Vitamin D is necessary for reproductive functions of the male rat. J Nutrition 1989;119:741–4.

82. Osmundsen B.C., Huang H.F., Anderson M.B. et al. Multiple sites of action of the vitamin D endocrine system: FSH stimulation of testis 1,25-dihydroxyvitamin D3 receptors. J Steroid Biochem 1989;34:339–43.

83. Uhland A.M., Kwiecinski G.G., DeLuca H.F. Normalization of serum calcium restores fertility in vitamin D-deficient male rats. J Nutrition 1992;122:1338–44.

84. Panda D.K., Miao D., Tremblay M.L. et al. Targeted ablation of the 25-hydroxyvitamin D 1ahydroxylase enzyme: evidence for skeletal, reproductive, and immune dysfunction. PNAS 2001;98:7498–503.

85. Ramlau-Hansen C.H., Moeller U.K., Bonde J.P. et al. Are serum levels of vitamin D associated with semen quality? Results from a cross-sectional study in young healthy men. Fertil Steril 2011;95:1000–4.

86. Penna G., Amuchastegui S., Cossetti C. et al. Treatment of experimental autoimmune prostatitis in nonobese diabetic mice by the vitamin D receptor agonist elocalcitol. J Immunol 2006;177(12):8504–11.

87. Tiwari A. Elocalcitol, a vitamin D3 analog for the potential treatment of benign prostatic hyperplasia, overactive bladder and male infertility. In: Drugs: the Investigational Drugs J 2009;12:2040–3410.

88. Manchanda P.K., Kibler A.J., Zhang M. et al. Vitamin D receptor as a therapeutic target for benign prostatic hyperplasia. Indian J Urol 2012;28(4):377–81.

89. Holick M.F., Binkley N.C., Heike A. et al. Treatment, and Prevention of Vitamin D Deficiency: An Endocrine Society Clinical Practice Guideline. J Clin Endocrinol Metab 2011;96(7):1911–30.

90. Heany R.P. Vitamin D in health and disease. Clin J Am Soc Nephrol 2008;3:1535–41.


Для цитирования:


Тюзиков И.А., Калинченко С.Ю., Ворслов Л.О., Тишова Ю.А. Витамин D, мужское здоровье и мужская репродукция. Андрология и генитальная хирургия. 2013;14(4):36-44. https://doi.org/10.17650/2070-9781-2013-4-36-44

For citation:


Tyuzikov I.A., Kalinchenko S.Y., Vorslov L.O., Tishova Y.A. Vitamin D, men's health and male reproduction. Andrology and Genital Surgery. 2013;14(4):36-44. (In Russ.) https://doi.org/10.17650/2070-9781-2013-4-36-44

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ISSN 2070-9781 (Print)