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Андрология и генитальная хирургия

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Роль микроРНК в сперматогенезе

https://doi.org/10.17650/2070-9781-2016-17-3-23-37

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Аннотация

Мужские половые клетки имеют сложный транскриптом. Помимо кодирующих белки матричных РНК в нем присутствует много некодирующих РНК, включая микроРНК. Известно, что микроРНК – важные регуляторы экспрессии генов. Они функционируют в основном посттранскрипционно, контролируя трансляцию их целевых мессенджеров – матричных РНК – и участвуя в каждом этапе дифференцировки мужских половых клеток. В данном обзоре продемонстрировано значение путей микроРНК для нормального сперматогенеза. Определена функциональная роль ряда микроРНК на различных этапах дифференцировки половых клеток. Рассмотрены микроРНК в сперматозоидах и семенной плазме человека в качестве потенциальных биомаркеров мужского бесплодия.

Об авторах

С. А. Руднева
ФГБНУ «Медико-генетический научный центр»
Россия
Москва, 115478, ул. Москворечье, 1


А. А. Хаченкова
ФГБНУ «Медико-генетический научный центр»
Россия
Москва, 115478, ул. Москворечье, 1


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Для цитирования:


Руднева С.А., Хаченкова А.А. Роль микроРНК в сперматогенезе. Андрология и генитальная хирургия. 2016;17(3):23-37. https://doi.org/10.17650/2070-9781-2016-17-3-23-37

For citation:


Rudneva S.A., Khachenkova A.A. Role of microRNAs in spermatogenesis. Andrology and Genital Surgery. 2016;17(3):23-37. (In Russ.) https://doi.org/10.17650/2070-9781-2016-17-3-23-37

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ISSN 2070-9781 (Print)
ISSN 2412-8902 (Online)