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Андрология и генитальная хирургия

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Современная тактика преодоления мужского бесплодия: селекция сперматозоидов по их способности к связыванию с гиалуроновой кислотой

https://doi.org/10.17650/2070-9781-2015-16-4-10-17

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Аннотация

Интрацитоплазматическая инъекция сперматозоида в ооцит широко применяется во всем мире в программах вспомогательных репродуктивных технологий при наличии мужского фактора бесплодия. Однако данный подход может допустить отбор единичного сперматозоида, несущего разные виды патологий. Сведение к минимуму любых потенциальных рисков, влекущих за собой возникновение нарушений в развитии эмбрионов (апоптоз, фрагментация эмбрионов, нарушение экспрессии генов, анеуплоидии), является крайне важным условием для уменьшения возможных отрицательных последствий, возникающих в результате манипуляций с половыми клетками. Процессы, на которые способен оказать влияние эмбриолог, должны быть выполнены как можно более безопасным и физиологичным способом. Данные постоянно увеличивающегося количества публикаций, сообщающих о положительном эффекте использования техники селекции сперматозоидов по связыванию с гиалуроновой кислотой, позволяют сделать вывод о высокой перспективности этого подхода при лечении мужского бесплодия методами экстракорпорального оплодотворения. Отбор сперматозоидов с улучшенными характеристиками, определяющими зрелость и генетическую целостность, предоставляет возможность улучшения параметров преимплантационного эмбриогенеза, оказывая, таким образом, положительное влияние на клинические исходы программ вспомогательных репродуктивных технологий.

Об авторах

А. В. Зобова
ФГБУ «Научный центр акушерства, гинекологии и перинатологии им. акад. В.И. Кулакова» Минздрава России
Россия

Отделение вспомогательных технологий в лечении бесплодия,

117997, Москва, ул. Академика Опарина, 4



А. Х. Дударова
ФГБУ «Научный центр акушерства, гинекологии и перинатологии им. акад. В.И. Кулакова» Минздрава России
Россия

Отделение вспомогательных технологий в лечении бесплодия,

117997, Москва, ул. Академика Опарина, 4



Г. К. Сахарова
ФГБУ «Научный центр акушерства, гинекологии и перинатологии им. акад. В.И. Кулакова» Минздрава России
Россия

Отделение вспомогательных технологий в лечении бесплодия,

117997, Москва, ул. Академика Опарина, 4



В. Ю. Смольникова
ФГБУ «Научный центр акушерства, гинекологии и перинатологии им. акад. В.И. Кулакова» Минздрава России
Россия

Отделение вспомогательных технологий в лечении бесплодия,

117997, Москва, ул. Академика Опарина, 4



Н. П. Макарова
ФГБУ «Научный центр акушерства, гинекологии и перинатологии им. акад. В.И. Кулакова» Минздрава России
Россия

Отделение вспомогательных технологий в лечении бесплодия,

117997, Москва, ул. Академика Опарина, 4



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Для цитирования:


Зобова А.В., Дударова А.Х., Сахарова Г.К., Смольникова В.Ю., Макарова Н.П. Современная тактика преодоления мужского бесплодия: селекция сперматозоидов по их способности к связыванию с гиалуроновой кислотой. Андрология и генитальная хирургия. 2015;16(4):10-17. https://doi.org/10.17650/2070-9781-2015-16-4-10-17

For citation:


Zobova A.V., Dudarova A.K., Sakharova G.K., Smol'nikova V.Y., Makarova N.P. Current approach to male infertility treatment: sperm selection procedure based on hyaluronic acid binding ability. Andrology and Genital Surgery. 2015;16(4):10-17. (In Russ.) https://doi.org/10.17650/2070-9781-2015-16-4-10-17

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ISSN 2070-9781 (Print)