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Андрология и генитальная хирургия

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Тестостерон и сердечно-сосудистые риски: мифы и новая правда о кардиологической безопасности андрогенозаместительной терапии у мужчин

https://doi.org/10.17650/2070-9781-2014-3-42-51

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Аннотация

В критическом обзоре литературы освещаются вопросы кардиологической безопасности терапии тестостероном у мужчин с сердечно-сосудистыми заболеваниями, основанные на доказательных исследованиях за последние 25 лет. Проводится детальный анализ ряда последних публикаций, вызвавших к себе неоднозначное отношение экспертов и исследователей в связи с демонстрируемой в них высокой частотой неблагоприятных кардиологических исходов у мужчин на фоне андрогенозаместительной терапии. Подавляющее большинство современных рандомизированных исследований доказали наличие связи между низким уровнем тестостерона и неудовлетворительным состоянием сердечно-сосудистой системы у мужчин старшего возраста, поэтому раннее выявление и правильная коррекция гипогонадизма у них может рассматриваться как эффективная профилактическая и терапевтическая кардиопротективная опция. Результаты неправильно спланированных исследований, обладающие низкой доказательностью в связи с погрешностями дизайна и статистической обработки материала, опубликованные в последнее время, следует, несмотря ни на что, активно изучать и анализировать для того, чтобы не только подвергать критике, но и извлечь из них научно-практическую пользу для более правильного понимания проблемы в целом. Авторы излагают свою точку зрения по данному вопросу и пытаются вскрыть возможные причины неоднозначных результатов последних публикаций по кардиологической безопасности препаратов тестостерона, в высокой степени которой они сами нисколько не сомневаются.

Об авторах

С. Ю. Калинченко
ФГБОУ ВПО «Российский университет дружбы народов»
Россия
Кафедра эндокринологии факультета повышения квалификации медицинских работников, Москва


Игорь Адамович Тюзиков
ООО Клиника «Гармония»
Россия
Ярославль


Л. О. Ворслов
ФГБОУ ВПО «Российский университет дружбы народов»
Россия
Кафедра эндокринологии факультета повышения квалификации медицинских работников, Москва


Ю. А. Тишова
ФГБОУ ВПО «Российский университет дружбы народов»
Россия
Кафедра эндокринологии факультета повышения квалификации медицинских работников, Москва


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Для цитирования:


Калинченко С.Ю., Тюзиков И.А., Ворслов Л.О., Тишова Ю.А. Тестостерон и сердечно-сосудистые риски: мифы и новая правда о кардиологической безопасности андрогенозаместительной терапии у мужчин. Андрология и генитальная хирургия. 2014;15(3):42-51. https://doi.org/10.17650/2070-9781-2014-3-42-51

For citation:


Kalinchenko S.Y., Tyuzikov I.A., Vorslov L.O., Tishova Y.A. Testosterone and cardiovascular risk: myths and new truth about cardiological safety of androgen replacement therapy in men. Andrology and Genital Surgery. 2014;15(3):42-51. (In Russ.) https://doi.org/10.17650/2070-9781-2014-3-42-51

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ISSN 2070-9781 (Print)
ISSN 2412-8902 (Online)